药物联合支气管肺灌洗治疗肺部多重耐药感染的疗效分析

Curative effect analysis of drugs combined with bronchoalveolar lavage in the treatment of lung multiple drug resistance infection

目的对药物联合支气管肺灌洗的临床疗效进行讨论,观察该种治疗方式对肺部多重耐药感染的临床治疗效果,为日后的临床治疗推广提供参考。方法肺部多重耐药感染患者80例为研究对象,随机分为观察组与对照组,每组40例。对照组患者给予常规抗感染、营养支持等治疗方式;观察组患者在对照组基础上,联合纤维支气管镜(纤支镜)进行支气管肺灌洗。观察组患者每天灌洗1次,持续灌洗1周,观察两组患者的临床症状变化、实验室检查指标以及身体情况的变化。结果经过治疗后,发现观察组患者的体温下降比较明显,患者的痰量也大幅度下降,呼吸频率、动脉血氧分压等方面具有明显改善,患者身体状况趋于良好。在两组患者康复情况的对比中,观察组总有效率为95.0%,显著优于对照组77.5%,两组差异具有统计学意义(P<0.05)。观察组患者未出现死亡患者,而对照组患者有2例死亡。结论采用药物联合支气管肺灌洗的方式,不仅可以较大程度的缓解肺部多重耐药感染患者的病痛,还可以持续治疗疾病,逐步恢复正常的生理指标,对改善患者生活质量以及延长寿命、缩短住院时间具有积极意义。

Objective To investigate the clinical effect of drugs combined with bronchoalveolar lavage therapy, to observe the curative effect of the therapy in the treatment of lung multiple drug resistance infection, and to provide references for future clinical treatment. Methods A total of 80 cases of lung multiple drug resistance infection were randomly divided into observation group and control group with 40 cases in each group. The control group was treated by conventional anti infection and nutrition support treatment; and the observation group received bronchoalveolar lavage through fiberoptic bronchoscopy in addition. The lavage conducted 1 time a day, and lasted for 1 week. The change of clinical symptoms, index of laboratory examination and physical condition were observed. Results After treatment, temperature and amount of phlegm of patients in the observation group were decreased obviously, and their respiratory rate and arterial partial pressure of oxygen had significantly improved. Physical condition of patients tended to be good. Comparison between the recovery condition of the two groups showed that the total effective rate of the observation group was 95.0%, and that of the control group was 77.5%. The difference was statistically significant （P〈0.05）. There was no death case in the observation group, while 2 death cases in the control group. Conclusion Applying drugs combined with bronchoalveolar lavage therapy can not only relive the pain of lung multiple drug resistance infection, but also provide continuously treatment and improve physiological index gradually. The therapy is significant for improving patients＇ life quality, prolonging life, and shortening hospital stays.