血清铁蛋白水平与2型糖尿病的关系研究

Association between serum ferritin level and type 2 diabetes mellitus

目的:探讨汉族人群中血清铁蛋白水平与2型糖尿病(type 2 diabetes mellitus,T2DM)间的相关性。方法:分别测定400例T2DM患者(T2DM组)、400例高血清铁蛋白非糖尿病(non-diabetes mellitus,NDM组)患者和400名健康体检人群(正常对照组)的空腹胰岛素、血清铁蛋白和血细胞分析(血红蛋白、血细胞比容、平均红细胞体积、平均血红蛋白)等指标。结果:空腹胰岛素指标在T2DM组与NDM组、健康对照组间差异有统计学意义(P<0.001);血清铁蛋白、血细胞比容、血红蛋白、平均红细胞体积等指标在T2DM组、NDM组及健康对照组两两之间差异存在统计学意义(P<0.001)。当T2DM患者的血清铁蛋白水平>292.5 mg/L时,其诊断T2DM的灵敏度和特异度分别为55.2%和91.6%,曲线下面积为0.82,血清铁蛋白与血细胞比容、血红蛋白及平均红细胞体积等指标相比,显示出与疾病间更好的风险关系。结论:血清铁蛋白水平升高与T2DM的高风险相关。

Objective： To study the association between serum ferritin level and type 2 diabetes mellitus （T2DM） in Chinese Han population. Methods： A total of 400 patients with type 2 diabetes mellitus （T2DM group）, 400 patients with high ferritin level but without type 2 diabetic mellitus（NDM group） and 400 healthy controls（control group） were enrolled. Fasting insulin （FINS） and serum ferritin （SF）, glycosylated hemoglobin （HbA1C） and parameters of blood cell count （Hb, Hct, MCV, MCH） were determined. Results： FINS in T2DM group was significantly different from that of the NDM group and control group （P〈0.001）. SF, Hct, Hb, MCV were significantly different between these 3 groups （P〈0.001）. When SF〉 292.5 mg/L was set as the cutoff value, the diagnostic sensitivity and specificity of type 2 diabetes mellitus were 55.2% and 91.6%, respectively; the area under ROC curve （AUC） was 0.82. SF showed a better correlation with risk of T2DM than Het, Hb and MCV. Conclusions： Increased ferritin levels is associated with a higher risk of T2DM.