期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

载脂蛋白A5调节三酰甘油代谢及其对心血管疾病影响 被引量：1

原文传递
导出
摘要 载脂蛋白A5（apolipoprotein A5,ApoA5）是血浆三酰甘油（triglyceride,TG）的一个关键调节因子。尽管其血浆浓度相对于其他已知载脂蛋白而言是很低的,但多年来,各地研究人员仍试图阐明体内ApoA5调节血浆TG的分子机制。关于ApoA5调节TG水平的分子机制持有2种观点,大致描述如下：①ApoA5增强了富含TG脂蛋白的分解代谢;
作者 华沙 赵建荣
机构地区 上海交通大学医学院附属瑞金医院卢湾分院心血管科
出处 《诊断学理论与实践》 2014年第3期336-340,共5页 Journal of Diagnostics Concepts & Practice
关键词 载脂蛋白 三酰甘油 心血管疾病 机制
分类号 R589.2 [医药卫生—内分泌]
  • 相关文献

参考文献39

  • 1Garelnabi M, Lor K, Jin J, et al. The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research[J]. Clin Biochem,2013,46(1-2):12-19.
  • 2Pennacchio LA, Olivier M, Hubacek JA, et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing[J]. Science, 2001,294(5540): 169-173.
  • 3van der Vliet HN, Sammels MG, Leegwater AC, et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration[J]. J Biol Chem, 2001,276(48):44512-44520.
  • 4Merkel M, Loeffler B, Kluger M, et al. Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipopro- teins by interaction with proteoglycan-bound lipoprotein lipase[J]. J Biol Chem,2005,280(22):21553-21560.
  • 5Kwiterovich PO Jr. Diagnosis and management of familial dyslipoproteinemias[J]. Curr Cardiol Rep,2013,15(6):371.
  • 6Weinberg RB, Cook VR, Beckstead JA, et al. Structure and interfacial properties of human apolipoprotein A-V[J]. J Biol Chem,2003,278(36):34438-34444.
  • 7Sharma V, Forte TM, Ryan RO. Influence of apolipoprotein A-V on the metabolic fate of triacylgly- cerol[J]. Curr Opin Lipidol,2013,24(2):153-159.
  • 8Schaap FG, Rensen PC, Voshol PJ, et al. ApoAV reducesplasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis[J]. J Biol Chem,2004,279(27):27941-27947.
  • 9Chien KL, Hsu HC, Chen YC, et al. Association between sequence variant of c.553 G > T in the apolipoprotein A5 gene and metabolic syndrome, insulin resistance, and carotid atherosclerosis[J]. Transl Res,2009,154(3):133-141.
  • 10Elosua R, Ordovas JM, Cupples LA, et al. Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study[J]. J Lipid Res,2006,47(5):990-996.

同被引文献24

  • 1Wei H J, Li YH, Shi GY, et al. Thrombomodulin domains attenuate atherosclerosls by inhibiting thrombin-lndueed endothelial cell acti- vation[J]. Cardiovasc Res, 2011, 92(2): 317 -327.
  • 2Kalz J, Ten Cate H, Spronk HM. Thrombln generation and athero- sclerosis [ J ]. J Thromb Thrombolysis, 2014, 37 ( 1 ) : 45 - 55.
  • 3Beppu T, Gil-Bernabe P, Boveda-Ruiz D, et al. High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double-deficient mice[J]. J Thromb Haemost, 2010, 8(11): 2514 -2522.
  • 4Henareh L, Jedefors C, Jogestrand T, et al. Intima-media thickness of common carotid and brachial arteries and prothrombin fragment 1 + 2 are associated with left ventrieular diastolic dysfunction in patients with myocardial infarction [ J ]. Eehoeardiography, 2010, 27(6): 651 -658.
  • 5Luszczak J, Undasa A, Gissel M, et al. Activated factor Ⅺ and tissue factor in aortic stenosis : links with thrombin generation [ J ]. Blood Coagul Fibrinolysis, 2011, 22(6) : 473 -479.
  • 6Quinn TJ, Gallaeher J, Deary IJ, et al. Association between circu- lating hemostatic measures and dementia or cognitive impairment: systematic review and nleta-analyzes [ J ]. J Thromb Haemost, 2011, 9(8) : 1475 -482.
  • 7Miyata M, Ikeda Y, Nakamura S, et al, Effects of valsartan on fibrinolysis in hypertensive patients with metabolic syndrome [ J ]. Cite J, 2012, 76(4) : 843 -851.
  • 8Narverud I, Iversen PO, Aukrust P,et al. Maternal familial hyper- cholesterolaemia (FH) confer sahered haemostatic profile in offspring with and without FH [ J ]. Thromb Res, 2013,131 ( 2 ) : 178 - 182.
  • 9Benes P, Muzik J, Benedik J,et al. Single effects of apolipoprotein B, (a), and E polymorphisms and interaction between plasminogen activator inhibitor-1 and apolipoprotein(a) genotypes and the risk of coronary artery disease in Czech male Caucasians [ J]. Mol Genet Metab, 2000, 69(2): 137- 143.
  • 10Rahimi Z, Vaisi-Raygani A, Pourmotabbed T. Association between apolipoprotein e4 allele, factor V Leiden, and plasma lipid and lipoprotein levels with sickle cell disease in Southern lran [ J]. Mol Biol Rep, 2011, 38(2) : 703 -710.

引证文献1

二级引证文献5

诊断学理论与实践
2014年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部