松弛素在急性心力衰竭中的研究进展

Research of Relaxin in Acute Heart Failure

急性心力衰竭(AHF)是临床常见疾病,因其具有高发病率、高致死率和高致残率而引起广泛关注。松弛素能增加心输出量、降低血管阻力、增加肾小球滤过率和肾血管流量,因此可使AHF患者受益。结合近年来有关松弛素的基础研究,本文总结归纳了松弛素在治疗AHF中的作用及其相关机制,并对松弛素作为一种治疗AHF的新药在前期临床试验中的结果进行简要介绍。

Summary Acute heart failure（AHF）, a common clinical disease, has caused much concern because of its high morbidity and mortality. Relaxin may benefit AHF patients with functions of increasing cardiac output, glo- merular filtration rate, renal vascular flow and reducing vascular resistance. The present review primarily focuses on the related mechanisms of relaxin in the treatment of AHF. and makes a brief summary of relaxin on its out- comes in preclinical trials as a new drug for AHF.