肝细胞癌肝外转移对患者生存预后的影响

Extrahepatic metastasis markedly impact on the survival in hepatocellular carcinoma patients

目的：探讨肝细胞癌（ HCC）肝外转移最常见的部位及对患者生存预后的影响。方法收集经PET/CT检查确诊HCC肝外转移的病例132例,对其HCC转移部位进行回顾性分析,同时行单因素、多因素生存分析。结果 HCC 肝外转移最常见的部位是淋巴结（54.5%,72/132）、骨（24.2%,32/132）和肺（21.2%,28/132）；单因素和多因素生存分析均提示淋巴结转移对患者生存预后有显著影响（P值均〈0.05）,而其他转移部位和生理指标对生存预后均无显著影响（P值均〉0.05）。结论淋巴结转移在HCC肝外转移最常见且可显著影响患者生存预后,及早诊断及治疗淋巴结转移病灶将能改善患者生存质量,延长生存时间。

Objective To investigate the most common sites and the impact of survival prognosis for patients in the extrahepatic metastasis of liver cancer. Methods One hundred and thirty-two cases confirmed with HCC extrahepatic metastasis by PET/CT examination were collected in our department. These cases were retrospectively analyzed, univariate and multivariate survival analysis were conducted. Results The most common sites of HCC extrahepatic metastasis were lymph nodes （54. 5%,72/132）, bone （24. 2%, 32/132） and lung （21. 2%, 28/132）, the univariate and multivariate survival analysis prompted to lymph node metastasis had a significant effect on survival prognosis （all P values 〈0. 05）, while other transfer locus and physiological indices had no significant effects （all P values 〉 0. 05）. Conclusions Lymph node metastasis in HCC extrahepatic metastasis is the most common and can significantly affect patients survival prognosis. Early diagnosis and treatment of lymph node metastasis in patients will be able to improve the quality of survival and prolong the survival time.