摘要
自噬是广泛存在于真核细胞中的生命现象。已有研究表明,自噬对维持细胞自身的稳定及细胞成分更新保持正常的生理状态起着至关重要的作用。近年来,研究发现自噬与生长发育、肿瘤以及心血管疾病的发生发展密切相关。进一步研究表明,自噬在不同病理环境下既能够促进血管生成,也能够抑制血管的生成。因此,阐释自噬在不同病理环境下调控血管生成的作用机制显得尤为关键。该文对自噬在心血管疾病中的作用尤其是对血管生成的作用研究进展进行综述,着重探讨自噬调控血管生成的作用机制,为后续的科学研究及指导临床提供重要参考。
Autophagy is a common phenomenon which widely ex-ists in eukaryotic cells. Researches have shown that autophagy plays a critical role in maintaining cellular hemostasis, cell com-ponents update and keeping a normal physiological state. In re-cent years, the study has found that autophagy is closely related to the growth, the development of cardiovascular diseases and tumors. Further studies show that in different pathological condi-tions, autophagy could both promote angiogenesis and inhibit the formation of blood vessels. Therefore, it is particularly critical to elucidate the mechanisms of autophagy in the regulation of angio-genesis in different pathological conditions. The role of autophagy in cardiovascular diseases especially in the regulation of angio-genesis is discussed in this paper. Besides, the paper also in-cludes the discussion about the mechanisms of autophagy in the regulation angiogenesis, which may provide references for follow-up research and clinical treatment.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第10期1347-1349,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81173190)
江苏省中医药管理局项目(No LZ11191)
江苏省高校优势学科建设工程资助项目(No ysxk-2010)
南京中医药大学中药学一级学科开放课题资助(No 2011zyx4-004)
关键词
自噬
生理功能
血管生成
心血管疾病
分子机制
治疗策略
autophagy
physiological function
angiogenesis
cardiovascular diseases
molecular mechanisms
therapy strate-gies