恩再适治疗带状疱疹后遗神经痛疗效评价及对BDNF表达的影响

Efficacy and mechanism of analgecine in the treatment of postherpetic neuralgia

目的:评价牛痘疫苗致炎兔皮提取物(恩再适)治疗带状疱疹后遗神经痛(PHN)的疗效及对脑源性神经营养因子(BDNF)表达的影响。方法:50例PHN患者随机分为两组,对照组给予加巴喷丁、甲钴胺和对乙酰氨基酚曲马多,治疗组在此基础上加用恩再适注射液,疗程14天。采用视觉模拟评分法(VAS)对患者进行疼痛评分并采用酶联免疫吸附法检测患者外周血中脑源性神经营养因子的表达。结果:治疗组疼痛评分较对照组明显减少(P<0.01),治疗组外周血中脑源性神经营养因子表达较对照组明显升高(P<0.01)。结论:恩再适能显著缓解带状疱疹后遗神经痛,其作用机制与BDNF升高密切相关。

Objective：To assess the efficacy and determine the possible mechanism of analgecine （ extracts from rabbit skin inflamed by vaccine virus for injection） in the treatment of post-herpetic neuralgia （ PHN） . Methods：Fifty patients with PHN were randomly divided into control group （ 25 cases） and experimental group （25 cases）. In addition to the therapy of gabapentin, mecobalamine and acetaminophen tramadol in control group,analgecine was given to the patients in the experimental group. After 14-days treatment, the therapeutic effects were evaluated using visual analogue scale （ VAS）,and the levels of brain-derived neuro-trophic factor were measured by enzyme linked immunosorbent assay. Results：Compared to the control group,the score of VAS was decreased （ P〈0.01） and the level of brain-derived neurotrophic factor were up-regulated （ P〈0.01） . Conclusion：Analgecine can reduce the pain of patients with PHN, in which the mechanism of the therapeutic effect is closely related to the increase in the level of brain-derived neurotrophic factor.