血必净注射液治疗百草枯中毒疗效的Meta分析

Meta analysis on efficiency of Xuebijing Injection in treatment of paraquat poisoning

目的运用Meta分析方法评价血必净注射液治疗百草枯中毒的疗效。方法检索Medline、Embase、Pubmed、Cochrane图书馆、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(维普)、万方数字化期刊全文库等数据库,对纳入的随机对照试验文献进行质量评价,并采用RevMan 5.0软件进行Meta分析。结局指标为动脉血氧饱和度(SaO2)、肾功能损害情况和死亡率。结果纳入研究的文献共8篇,均为中文文献。结果显示,SaO2合并效应值WMD=0.18,95%CI(0.11,0.24),P<0.000 01;肾功能损害情况合并效应值WMD=-224.28,95%CI(-318.99,-129.56),P<0.000 01;死亡率OR=0.31,95%CI(0.18,0.54),P<0.000 1,表明治疗组疗效明显优于对照组。结论血必净注射液治疗百草枯中毒有一定优势。但因目前纳入研究的文献质量较低,可靠的结果有待更多高质量试验进一步验证。

Objective To evaluate the efficacy of Xuebijing Injection in treatment of paraquat poisoning by meta analysis. Methods Medline, Embase, Pubmed, Cochrane Library, China Journal Full-text Database （CNKI）, Chinese Science and Technology Journal Full-text Database （VIP）, Wangfang Database, etc were retrieved by computer, and the quality assessment of qualified random control trials were evaluated. Meta analysis was carried out by RevMan 5.0 software. The outcomes included arterial blood oxygen saturation （SaO2）, renal function damage and mortality rate, Results Eight trials were included in the study, and all of them were in Chinese. Meta analysis indicated that SaO2： WMD = 0.18, 95%CI （0.11, 0.24）, P 〈 0.000 01; renal function damage： WMD = -224.28, 95%CI （-318.99, -129.56）, P 〈 0.000 01; mortality rate： OR = 0.31, 95%CI （0.18, 0.54）, P 〈 0.0001. The efficacy of the treatment group was better than that in the control group, Conclusion Xuebijing Injection has certain advantages in the treatment of paraquat poisoning. Due to the limitation by the unsatisfactory quality of the inclusive literatures, the conclusions of the study require higher quality of trials to be further analyzed.