肾阳虚型不育症患者生殖激素水平和精液参数的变化及其相关性研究

Changes of Sex Hormone Levels and Semen Parameters in Kidney-Yang Deficiency Type Infertility Patients and Their Correlation

目的：观察肾阳虚型男性不育症患者生殖激素水平和精液参数的变化并探讨其相关性。方法：对符合研究纳入标准的100例肾阳虚型不育症患者为研究组,另外选择40名正常生育男性为健康对照组,均在上午8：00-10：00留取精液和静脉血液标本,进行精液分析检测和性激素6项、抑制素B（INHB）检测分析。结果：研究组T、INH-B水平显著低于正常对照组,PRL水平显著高于正常对照组（均P〈0.01）。研究组在精子活力和精子活率、精液量上显著低于正常对照组（P〈0.01）,液化时间显著延长（P〈0.05）。相关性研究表明：对照组LH与a级百分比、a＋b＋c级百分比呈正相关（P〈0.05）;FSH与a＋b级百分比、a＋b＋c级百分比呈负关（P〈0.05,P〈0.01）;T与b级百分比、a＋b＋c级百分比呈负相关（P〈0.05）;INH-B则呈正相关（P〈0.01）。研究组FSH与精子各级百分比呈显著负相关（均P〈0.01）;E2和PRL均与a级百分比、a＋b级百分比呈正相关（P〈0.01或P〈0.05）;精子畸形率与FSH、INH-B负相关显著（P〈0.01,P〈0.05）。结论：肾阳虚型男性不育症患者多项精液参数和性激素与正常生育男性存在显著差异,其多种性激素与精液参数具有相关性,可能存在多种激素调控通道的协同作用。

Objective：To observe the changes of sex hormone levels and semen parameters in kidney -yang deficency type infertility patients and explore the correlation.Methods：100 Cases with kidney-yang deficency type infertility patients were taken as experimental study group , 40 health men were taken as control group, spec-imens of semen and blood samples were taken in the morning 8：00 to 10：00 to analyze semen , sex hormone changes and determining inhibition B （ INHB）.R esults：T and INH-B levels in the study group were signifi-cantly lower than those in the control group , PRL level was significantly higher than that in the control group （ all P〈0.01 ）.The sperm motility and sperm vitality , semen volume in the study group were significantly lower than those in the control group （ P〈0.01 ） , the liquefaction time was significantly longer than that of the control group （ P〈0.05 ）.In the control group , LH was significantly positive correlated with a grade percentage , a＋b＋c grade percentage （ P〈0.05 ） ,FSH was significantly negative correlated with a ＋b grade percentage and a ＋b＋c-grade percentage （ P〈0.05 ,P〈0.01 ） , T was significantly negative correlated with b grade percentage and a＋b＋c grade percentage（P〈0.05）,INH-B was significantly positive correlated with b grade percentage and a＋b＋c grade percentage （ P〈0.01 ）.In the exprimental study group , FSH was significantly negative correlated with every sperm grade percentage （all P〈0.01）,E2 was significantly positive correlated with a grade percentage , a＋b grade percentage （ P〈0.01 ,P〈0.05 ） ,;PRL was significantly positive correlated with a grade percent-age , a＋b grade percentage （ P〈0.05 ）;the sperm deformity rate had significant negative correlation with FSH , INH-B（P〈0.01,P〈0.05）.Conclusion：There were obvious differences between in kidney -yang deficency type infertility patients and health men on the sex hormone levels and semen parameters and there were correla -tion between hormone changes and semen parameters changes , there may be a variety of hormone regulation of channel synergies.