摘要
细菌由不耐药转变为耐药尤其是转变为多重耐药是如今临床上面对的严峻现状。耐药机制的产生有多种原因,目前国内外与之研究较多的是整合子系统,整合子是捕获外源基因并使之转变为功能性基因的表达单位,通过转座子和接合质粒在细菌中传播。整合子(integron)包括一个特定的重组位点,里面可以插入的整合与编码某些功能的基因,被称为基因盒(gene cassette)。本文将对细菌的多重耐药与整合子-基因盒的关系进行综述。
It was a hard clinical situation of the sensitive bacteria become antibiotic resistance bacteria, especially multi-resistance bacteria. There are so many causations should explain why multiple resistance coming into being, recent study on this subject was integron system both at home and abroad, lntegrons are gene capture and expression systems that disseminate resistance gene via plasmids and transposition element. The integron includes a site-specific recombination system capable of integrating and expressing genescontained in structures called gene cassettes.This review was conducted to introduce the structures and functions of integrons and mechanisms that control integron-medialed events linked to multiple resistance.
出处
《武警后勤学院学报（医学版）》
CAS
2014年第9期786-789,共4页
Journal of Logistics University of PAP（Medical Sciences）
关键词
多重耐药
细菌
整合子
Multiple resistance
Bacteria
Integron
