大鼠尾静脉注射姜黄素固体脂质纳米粒的药动学研究

Pharmacokinetics Study of Curcumin Solid Lipid Nanoparticles by Intravenous Injection in Rats

目的:研究SD大鼠尾静脉注射姜黄素固体脂质纳米粒后的药动学情况。方法:大鼠尾静脉注射姜黄素固体脂质纳米粒和游离药姜黄素后,不同时间点取血浆,HPLC测定血浆中姜黄素的含量,得其药时曲线,并以DAS软件分析处理药动学数据。结果:姜黄素固体脂质纳米粒和游离药姜黄素的药动学参数分别如下:AUC0-t为(173.09±44.81)μg·h/L和(114.83±13.19)μg·h/L,AUC0-∞为(196.56±35.25)μg·h/L和(120.66±13.95)μg·h/L,t1/2为(5.95±2.05)h和(1.46±0.03)h,姜黄素固体脂质纳米粒的AUC0-t、AUC0-∞和t1/2分别提高了1.50、1.63、4.08倍。结论:姜黄素固体脂质纳米粒在大鼠体内消除慢,能明显提高姜黄素的生物利用度。

Objective： To study the intravenous pharmacokinetics of curcumin solid lipid nanoparticles in SD rats.Methods： Rats were administrated with（ iv） curcumin solid lipid nanoparticles and curcumin solution（ 8.0 mg /kg）,respectively.Blood samples were collected and curcumin in blood plasma was determined by HPLC.Compartmental pharmacokinetics was analyzed by DAS software.Results： After intravenous administration,the AUC0-t、AUC0-∞and t1 /2of curcumin solid lipid nanoparticles were 1.50-fold,1.63-fold and 4.08-fold higher than those of curcumin solution as（ 173.09 ± 44.81） μg · h /L vs.（ 114.83 ± 13.19） μg · h /L,（ 196.56 ±35.25） μg·h/L vs.（ 120.66 ±13.95） μg·h/L and（ 5.95 ±2.05） h vs.（ 1.46 ±0.03） h.Conclusion： The curcumin solid lipid nanoparticles is eliminated more slowly.The bioavailability of curcumin in rats increases remarkably compared with that of curcumin solution after intravenous administration.