肿瘤新型标志物高尔基体蛋白73的临床应用

Progress of GP73 as a new tumor marker for clinical application

高尔基体蛋白73（ GP73）是定位于高尔基体的一种新型跨膜糖蛋白，正常情况下，其主要表达于人胆管上皮细胞中。近年来的研究发现，GP73在肝癌、前列腺癌、肺癌、肾癌等多种肿瘤组织中呈高表达状态，有望作为一种潜在的新型肿瘤标志物应用于临床肿瘤诊断。（中华检验医学杂志，2014，37：661-664）

Golgi protein 73, a novel Golgi-localized transmembrane glycoprotein , is normally expressed in biliary epithelial cells of human tissues.Researches show that GP73 is overexpressed in many tumor tissues, such as hepatocellular carcinoma , prostate cancer, lung adenocarcinoma, renal cell cancer, and so on, which may play on important role in cancer diagnosis as a novel tumor marker.