摘要
前列腺癌是男性人群中最常见的恶性肿瘤之一,雄激素受体可通过与基因组中雄激素反应元件结合并与共调解因子相互作用调控下游靶基因的表达从而参与前列腺癌的发生发展以及前列腺癌由雄激素依赖到非依赖的转变过程。染色质免疫共沉淀技术与PCR、基因芯片、高通量测序技术的结合使得对雄激素受体调控的靶基因研究有了最新进展,为雄激素去势治疗产生耐药的分子机制的研究提供新的思路。(中华检验医学杂志,2014,37:673-677)
Prostate cancer is one of the most common malignant tumor of male population in the West.Via binding to androgen response element in the genome and interacting with co-regulators,androgen receptor can participate in the development of prostate cancer and the convertion from androgen dependent prostate cancer to androgen independent prostate cancer.Chromatin immunoprecipitation ,coupled with PCR , chip,and high-throughput sequencing ,makes a huge progress in the study on the downstream target genes of androgen receptor and provide a new way to understand the molecular mechanisms of castration -resistant prostate cancer.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2014年第9期673-677,共5页
Chinese Journal of Laboratory Medicine
基金
国家自然科学基金资助项目(81271917)
关键词
前列腺肿瘤
受体
雄激素
染色质免疫沉淀法
基因表达调控
Prostatic neoplasms
Receptors,androgen
Chromatin immunoprecipitation
Gene expression regulation