sTREM-1、PCT在社区获得性肺炎早期诊断中的价值

Significance of Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Procalcitonin in the Early Diagnosis of Community-acquired Pneumonia

目的:探讨可溶性髓系细胞触发受体-1(soluble triggeringreceptorexpressed on myeloidcells-1,sTREM-1)、降钙素原(procalcitonin,PCT)在社区获得性肺炎(community-acquired pneumonia,CAP)早期诊断中的价值。方法:选择48例CAP住院患者(其中重症肺炎8例)和病毒性上呼吸道感染患者20例,所有病例均在入院后24小时内取血清,采用酶联免疫测定法(ELISA法)测定其血清sTREM-1、PCT水平,并应用受试者工作特征曲线(receiver operating characteristic curve,ROC曲线)分析二者对CAP的诊断价值。结果:入院后24小时内,普通肺炎患者、重症肺炎患者血清sTREM-1、PCT水平均明显高于对照组,且重症肺炎组明显高于普通肺炎组,差异均具有统计学意义(P<0.01)。二者诊断CAP的ROC曲线下面积分别为0.884、0.788,联合二者诊断CAP的ROC曲线下面积为0.921。结论:sTREM-1、PCT均可作为CAP早期诊断有价值的参考标志物,sTREM-1比PCT更有参考价值,联合检测血清sTREM-1、PCT水平对CAP的早期诊断价值高于单一指标。

Objective： To investigate the value of serum soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） and procalcitonin （PCT） in early diagnosis of community-acquired pneumonia. Methods： 48 inpatients with pneumonia （include 8 patients with severe pneumonia） and 20 patients with Viral upper respiratory tract infection as control were included. Serum sTREM-1 and PCT were detected by enzyme-linked immunosorbent assays（ELISA） within 24 hours. The receiver operating characteristic eurve（ROC curve） was used to check diagnostic value of the detections. Results： The concentrations of sTREM-1 and PCT in serum were significantly hisher than those in controls with Statistical significance. The concentrations of sTREM-1 and PCT in severe pneumonia group were significantly hisher than those in common pneumonia group with Statistical significance. The area under the ROC curve of sTREM-1, PCT were respectively 0.884, 0.788, which was 0.921 by combination of sTREM-1 and PCT. Conclusion： Both sTREM-1 and PCT are good markers in the early diagnosis of CAP, combined detection of serum sTREM-1, PCT levels was more valuable for early diagnosis of CAP.