微波灭活与射频消融术中联合应用于治疗四肢骨肉瘤的疗效分析

The Analysis of Clinical Therapeutic Effect in Conbined Application of Microwave Inactivation and Radio Frequency Ablation in the Treatment of Osteosarcoma in All four Limbs

目的:探讨微波灭活与射频消融技术联合应用治疗骨肉瘤的临床疗效。方法:回顾性分析我院自2007年至2012年间手术治疗的具有完整临床资料的骨肉瘤患者29例,其中发生于肱骨上端9例,股骨远端12例,胫骨上段5例,盆腔3例,并经TNM分期。术前采取动脉植入式化疗泵化疗2疗程,并于术中给以微波灭活与射频消融方法联合灭火肿瘤瘤体,刮除肿瘤后行骨水泥填充。术后随访8-60个月,平均50±2月。结果:29例患者中死亡1例,局部复发3例,远端转移2例。结论:微波灭活与射频消融术中联合应用于恶性骨肿瘤术中瘤体灭活,可以达到良好的肿瘤灭活效果,减少术中出血,大大提高患者生存率及降低复发率。

Objective： To discuss the clinical effects of combined application of microwave- induced hyperthermia and RFA in treating malignant bone tumors. Methods： A retrosp-ective analysis was conducted about the clinical data of 29 cases with maglinant bone tumors who were treated in our hospital from 2007 to 2012. Among the cases, 9 were humerus head; 12 were distal femur; 5 were Tibial upper segment; 3 were pelvic cavity. We did preoperative chemotherapy for 2 courses by using arterial chemotherapy implantable pump, and after that we operated them by microwave- induced hyperthermia and radiofrequency Ablation in the intraoperation. Filling with bone ce-ment after digging out all of the tumor organization. All cases are followed-up by 8-60 months postoperation, on average of 50＋ 2 months. Results： In 29 patients, only 1 died, 3 cases of local recurrence, 1 of metastasis. Conclusion： Microwave inactivation conbined with radio frequency ablation application in malignant bone tumors can lead us to achieve good inactivation effect, reduce the intraoperative bleeding, greatly improve the patients survival rate and decrease the recurrence rate.