生物标志物在前列腺炎中的研究进展

Progress of Study on Biomarkers of Prostatitis

前列腺炎是男性泌尿系统的常见疾病,由于前列腺炎存在病因和发病机制复杂,导致临床症状表现多种、药物治疗缺乏特异性和复发率较高等问题,因此前列腺炎的诊断、治疗和预后判断标准一直是临床关注的焦点。目前还没有诊断前列腺炎的"金标准",而生物标志物的检测有助于临床诊断、治疗和预后诊断,本文检索近年相关,对敏感性较高和特异性较好的一些前列腺炎生物标志物(细胞因子和趋化因子等)及今后研究的侧重点进行综述,从而为前列腺炎的诊断、分型治疗和预后观察提供依据。

Prostatitis is a common genitourinary disease of adult male. Diagnosis, treatments and prognostic monitoring of prostatitis have always been the focus of clinical attention, as a result of its setbacks, such as complex pathogenesis and clinical symptoms, lacking specificity in medication and its high rate of recurrence and so on. Currently, there isn＇t a “golden standard” in diagnosis of prostatitis, while the detection of biomarkers can be helpful for the diagnosis, treatment and prognostic monitoring of prostatitis. In this paper, we review the prostatitis biomarkers （cytokines/chemokine） which have high sensibility and good specificity, and also, we review the future research emphasis. What we have studied may offer reference for diagnosis, treatment and prognostic monitoring of prostatitis.