四跨膜蛋白超家族在消化系统恶性肿瘤中的生物学行为的研究进展

Review of The Biological Significance of Transmembrane 4 Super Family in Digestive System Cancer

目的总结四跨膜蛋白超家族(TM4SF)在消化系统恶性肿瘤中的作用及其机理。方法检索近年的国内外相关文献,对消化系统恶性肿瘤中TM4SF的生物学行为及其作用机理的研究进展进行综述。结果 TM4SF在消化系统恶性肿瘤(如胰腺癌、胃癌、结直肠癌、肝癌及食管癌)的转移及浸润过程中发挥重要的促进作用。TM4SF通过固定在细胞膜上的微区域控制着细胞的黏附、运动、侵袭、增殖等生物学行为。结论 TM4SF可能是消化系统恶性肿瘤转移、预后等的预测指标,并可能是消化系统恶性肿瘤的治疗靶点。

Objective To explore the effect and mechanisms of transmembrane 4 super family（TM4SF） in digestive system cancer. Methods Articles were reviewed to discuss the biological characteristics of TM4 SF in digestive system cancer. Results TM4 SF played an important role in migration and invasion of digestive system cancer,including pancreatic cancer,gastric cancer,colorectal cancer,hepatic cancer,esophageal cancer,and so on.TM4 SF modulated the cell biological activities by microdomains which were fixed on cell membrane,such as adhesion,migration,invasion,and proliferation. Conclusions TM4 SF may be used to predict the metastasis and prognosis of digestive system cancer and may be the targets of therapy of it in the future.