摘要
库欣综合征是由长期过量皮质醇所产生的一组症候群。患者体内高浓度的糖皮质激素可通过损伤神经细胞、诱导神经细胞凋亡、抑制神经再生和调节突触可塑性等多种方式破坏大脑的结构及功能,产生抑郁及认知障碍等精神症状,并可能伴随有海马等结构的萎缩。手术、米非司酮等药物治疗可使精神症状得到改善。
Cushing＇s syndrome describes the signs and symptoms associated with prolonged exposure to excess cortisol.Inappropriately high levels of the glucocorticoid harms the brain＇s structure and function by damaging nerve cells,inducing apoptosis of neurons,suppressing neurogenesis,modulating synaptic plasticity,etc.Thus neuropsychiatric disorders as depression and cognitive impairment appear,with or without hippocampal atrophy.Surgery and medical treatment like mifepristone may improve those symptoms.
出处
《基础医学与临床》
CSCD
北大核心
2014年第10期1438-1441,共4页
Basic and Clinical Medicine
关键词
库欣综合征
糖皮质激素
精神症状
Cushing＇s syndrome
glucocorticoid
neuropsychiatric disorders
