阿尔茨海默病相关影响因素的病例对照研究

A case-control study on related influence factors of Alzheimer's disease

目的探讨阿尔茨海默病（AD）的发病影响因素,为AD的预防提供理论参考。方法以2013年2月-2014年5月在吉林大学第一医院就诊的AD患者31例和同期在该院住院的认知功能正常患者35例为对象进行病例对照研究,经过统计学分析筛选出AD发病的影响因素。结果食用豆制品、喜好与朋友交往、负性生活事件、规律服用降血压药物的OR值及95%CI分别为0.067（0.010-0.443,P=0.005）、0.061（0.012-0.296,P=0.001）、23.581（1.751-317.589,P=0.017）、0.145（0.029-0.720,P=0.018）。病例组和对照组血清镁含量之间的差异有统计学意义（P〈0.01）,AD患者血清锌和叶酸含量低于正常水平。结论食用豆制品、喜好与朋友交往、规律服用降血压药物可能是AD发生的保护因素;负性生活事件可能是AD发生的危险因素。

Objective To investigate the main influence factors of Alzheimer＇s disease（ AD） and provide a theoretical reference for AD prevention. Methods A total of 31 cases of outpatients with Alzheimer＇s disease and 35 cases of patients with normal cognitive function were sampled at The First Hospital of Jilin University from February 2013 to May2014. Then a case-control study was carried out to identify the influence factors of AD through statistical analysis. Results The OR values and 95% CI of eating soy products,socializing with friends,suffering from negative life events,using antihypertensive drugs regularly were 0. 067（ 0. 010 - 0. 443,P = 0. 005）,0. 061（ 0. 012 - 0. 296,P = 0. 001）,23. 581（ 1. 751- 317. 589,P = 0. 017）,0. 145（ 0. 029 - 0. 720,P = 0. 018）. There was significant difference between case group and control group in the content of serum magnesium（ P〈 0. 01）,The content of serum zinc and folic acid in patients with AD was lower than normal level. Conclusion Eating soy products,socializing with friends,and using antihypertensive drugs regularly may be protective factors of AD; suffering from negative life events may be the risk factor of AD.