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脂磷壁酸的提取工艺及免疫功能的研究 被引量：1

The extraction process and immune function of lipoteichoic acid
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摘要 目的确定婴儿双歧杆菌脂磷壁酸(LTA)的最佳提取工艺及其免疫调节作用。方法通过对不同方法提取婴儿双歧杆菌LTA的测定及对植瘤小鼠淋巴细胞的转化来探讨LTA对小鼠细胞免疫的调节作用。结果采用脱脂后水法提取效果最好,与对照组和全菌组相比,LTA使淋巴细胞转化增加。结论婴儿双歧杆菌及其LTA均有免疫功能,但LTA的效果要优于婴儿双歧杆菌。 Objective To identify the optimum extraction process and immune regulation effect of lipoteichoic acid（ LTA） from Bifidobacterium infantis. Methods The regulatory effect of LTA on cellular immunity of mice was discussed,based on determination of the content of Bifidobacterium infantis LTA by different extraction process and lymphocyte transformation in mice with implanted tumor. Results The best extraction effect was seen in water extraction after degreasing. In comparison with control group and whole bacterium group,LTA increased lymphocyte transformation. Conclusion Both Bifidobacterium infantis and LTA can inhibit tumor,but the effect of LTA is better than that of Bifidobacterium infantis.
作者 付艳茹 黄少磊 龚虹 张烨 高仙灵 武岳 刘彦民
机构地区 呼和浩特职业学院 内蒙古双奇药业有限公司
出处 《中国微生态学杂志》 CAS CSCD 2014年第9期998-1001,共4页 Chinese Journal of Microecology
基金 呼和浩特科技项目(2012-I-1-3)
关键词 婴儿双歧杆菌 脂磷壁酸 提取 免疫功能 Bifidobacterium infantis Lipoteichoic acid Extraction Immuniological function
分类号 R378.992 [医药卫生—病原生物学]
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参考文献13

  • 1Fischer W. Physiology of lipoteichoic acids in bacteria [ J ]. Adv Microb Physiol, 1988, 29: 233.
  • 2Simpson WA, Ofek I, Beachey EH, et al. Binding of streptococcal lipoteichoic acid to the fatty acid binding sites on serum albumin [J].J Biol Chem, 1980, 255(13) : 6092-6097.
  • 3Archibald AR, Baddiley J. The ribitol teichoic acid from Lactobacil- lus arabinosus walls:isolation and structure of ribitol glucosides [ J ]. BiochemJ, 1961, 81(10): 124-34.
  • 4Archibald AR, Armstrong JJ, Baddiley J, et al. Teichoic acids and the structure of bacterial walls [J]. Nature, 1961, 191(8) : 570-572.
  • 5Archibald AR, Baddiley J, Button D. The glycerol teichoic acid of walls of staphlococcus lactis I3 [J]. Biochem J, 1968, 110 (3) : 543-557.
  • 6Hughes RC. The cell wall of bacillus lichenifonnis N. C. T. C. 6346. Linkage between the teichumnic acid and mucopeptide components [J].BioehemJ, 1970, 117(3): 431-439.
  • 7Archibald AR, Baddiley J, Button D. The membrane teiehoic acid of Staphylococcus lactis I3 [ J ]. Biochem J, 1968, 110 ( 3 ) : 559- 563.
  • 8Kuwano K, Akashi A, Matsu-ura I, et al. Induction of macro- phage-mediated production of tumor necrosis factor alpha by an L- form derived from Staphylococcus aureus[ J]. Infect Immun, 1993, 61(5) : 1700-1706.
  • 9Wieken AJ, Gibbens JW, Knox KW. Comparative studies on the i- solation of membrane lipoteichoic acid from LactobaciUus fermenti [J].J Bacteriol, 1973, 113(1): 365-372.
  • 10Sutcliffe IC, Hogg SD. Extraction of lipoteichoic acid from Strep- toeoous mutans with the non-ionic detergent Triton X-114 [J]. J Mi- crobiol Methods, 1993, 17(3):215.

二级参考文献4

共引文献21

同被引文献13

  • 1Fischer W. Physiology of lipoteichoic acids in bacteria[ J]. Adv Mi- crob Physiol, 1988, 29(1) : 233.
  • 2Simpson WA, Ofek l, Beachey EN, et al. Binding of streptococcal lipoteichoic acid to the fatty acid binding sites on serum albumin [J]. Biolog Chem, 1980, 255(13) : 6092-6097.
  • 3Archibald AR, Baddiley J. The ribitol teichoic acid from Lactobacil- lus arabinosus walls: isolation and structure of ribitol glucosides [J].BiochemJ, 1961, 81(1): 124-134.
  • 4Archibald AR, Armstrong JJ, Baddiley J, et al. Teichoic acids and the structure of bacterial walls[ J]. Nature, 1961, 8 ( 191 ) : 570- 572,.
  • 5Archibald AR, Baddiley J, Button D. The glycerol teichoic acid of walls of staphlococcus lactis I3 [ J]. Biochem J, 1968, 110 ( 3 ) : 543-557.
  • 6Hughes RC, The cell wall of bacillus licheniformis Archibald A J, Armstromg JJ, Baddiley J, N. C. T. C. 6346. Linkage between the teichuronie acid and mueopeptide components [ J ]. Biochem J, 1970, 117(3): 431-439.
  • 7Archibald AR, Baddiley J, Button D. The membrane teiehoic acid of Staphylococcus lactis 13 [ J]. Bioehem J, 1968, 110 (3) : 559- 563.
  • 8Kuwano K, Akashi A, Matsu-ura I, et all. Induction of macro- phage-mediated production of tumor necrosis factor alpha by an L- form derived from Staphylococcus aureus [ J ~. Infect Immun, 1993, 61(5) : 1700 -1706.
  • 9Wicken AJ, Gibbens JW, Knox KW. Comparative studies on the i- solation of membrane lipoteichoie acid from Lactobaeillus fermenti [J].J Bacteriol, 1973, 113(1) : 365-372.
  • 10Sutcliffe IC, Hogg SD. Extraction of lipoteichoic acid from Strep- toeoous mutans with the non-ionic detergent Triton X-114 [ J ]. J Mi- crobiol Methods, 1993, 17(3) : 215.

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中国微生态学杂志
2014年 第9期

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