妊娠期妇女生殖道大肠埃希菌感染与妊娠不良结局分析

Reproductive tract EIEC infection and adverse pregnancy outcome in pregnant women

目的探讨妊娠期妇女生殖道大肠埃希菌感染对妊娠不良结局的影响。方法回顾性分析2011年1月至2013年12月在石家庄市第四医院住院孕产妇共2 053例,进行阴道分泌物细菌培养,对大肠埃希菌培养阳性组与正常对照组的妊娠结局进行分析,以探讨妊娠合并生殖道大肠埃希菌感染与围产期并发症的关系。结果在2 053例围产期妇女中,无致病菌组(对照组)为1230例,大肠埃希菌培养阳性组(感染组)为103例,总患病率为5.02%。感染组与对照组的绒毛膜羊膜炎的发生率分别为78.64%、12.20%(P<0.01),产褥感染率分别为24.27%、3.41%(P<0.01),新生儿黄疸的发生率58.25%、12.36%(P<0.01),胎膜早破率分别为11.65%、10.57%(P>0.05),早产率分别为3.88%、3.09%(P>0.05),胎儿窘迫的发生率2.91%、2.76%(P>0.05),低体重儿的发生率1.94%、2.03%(P>0.05)。结论妊娠期妇女生殖道大肠埃希菌感染与绒毛膜羊膜炎、产褥感染及新生儿黄疸的发生相关,孕期及早发现、诊断、治疗妊娠期妇女生殖道大肠埃希菌感染是有重要意义。

To study the reproductive tract EIEC infections and adverse pregnancy outcome in pregnant women.Methods A retrospective analysis was conducted among 2,053 pregnant women who were examined between January 2011 and December 2013. The relationship between reproductive tract EIEC infection and pregnancy complications were discussed. Results The prevalence of EIEC infection in pregnant women was 5. 02%. The rates of chorioamnionitis,puerperal infection and neonatal jaundice were significantly higher in EIEC infection group than those in control group（ P 〈0. 05）. There were no significant differences in premature rupture of membranes,preterm labor,fetal distress and incidence of low birth weight infant. Conclusion Reproductive tract EIEC infection is closely associated with chorioamnionitis,puerperal infection and neonatal jaundice. Routine screening and treatment of EIEC infection in pregnant women should be carried out earlier.