人感染H7亚型禽流感事件

Human infection of subtype H7 avian influenza

本研究综述了自1959年以来国内外发生的人感染H7亚型禽流感事件。大多数是在家禽爆发禽流感期间,农场工人在处置感染鸡群过程中被暴露而感染;也有曾接触活禽或曾到过活禽市场而感染;有经禽流感病毒致病的哺乳动物(海豹)感染于人或实验室感染(事故)所致。引起人感染的H7亚型中已知有H7N2、H7N3、H7N7以及2013年在中国发现的新的致病亚型H7N9。H7N2、H7N3、H7N7感染以结膜炎为主,大多为轻症;而H7N9感染以严重的呼吸道感染为特征,表现为重症肺炎,呼吸窘迫综合症,病死率高达33.6%。

This paper reviewed the events of human subtype H7 avian influenza infection happened in the world since 1959. Most of the infections was due to exposure to avian influenza virus in culling of infected poultry flock during avian influenza outbreak,contacting with live poultry,visiting live poultry market,transmission of the virus to human beings from infected mammal（ seals）,and laboratory infections（ accidents） etc.. So far,the H7 subtypes that causes human avian influenza have been found to be H7N2,H7N3 and H7H7 as well as a novel pathogentic subtype H7N9 in 2013 in China. Most of H7N2,H7N3 and H7N7 infection cases were conjunctivitis with mild symptoms,while most of H7N9 infection cases featured severe respiratory diseases,including severe acute respiratory distress syndrome,with a mortality of 33. 6%.