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免疫因素及cccDNA与HBV的持续感染 被引量：1

Immunology and cccDNA in hepatitis B virus persistence
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摘要 由于乙肝疫苗普遍接种,乙型肝炎的流行已经下降,但慢性乙型肝炎(CHB)仍是严重的全球性公共卫生问题。超螺旋共价闭合环状DNA(cccDNA)作为原始转录模板,逃避机体免疫及抗病毒药物清除,在HBV持续感染中发挥重要作用。基于调节患者对HBV的免疫功能研究新的治疗策略以清除细胞核内cccDNA可能成为根除HBV持续感染的途径。 Since the introduction of hepatitis B vaccine,the worldwide prevalence of hepatitis B infection has fallen. However,chronic infection remains a global health challenge. HBV covalently closed circular DNA（ cccDNA）plays a key role in the persistence of the infection,as the transcriptional template it＇s very stable in quiescent hepatocytes. Development of new drugs and strategies to improve antiviral immunity and depletion of the cccDNA reservoir may eradicate persistent HBV infection
作者 柳鹏程 陈默 岳伟 邵远 张岭漪
机构地区 兰州大学第二医院消化疾病临床医学中心 兰州大学第一医院感染科 兰州大学第二医院肝病科
出处 《中国微生态学杂志》 CAS CSCD 2014年第9期1111-1115,共5页 Chinese Journal of Microecology
基金 兰州大学第二医院科研项目(YJ2010-09)
关键词 乙型肝炎病毒 慢性乙型肝炎 免疫 CCCDNA Hepatitis B virus Chronic hepatitis B Immunology cccDNA
分类号 R446.5 [医药卫生—诊断学]
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参考文献47

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二级参考文献20

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中国微生态学杂志
2014年 第9期

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