PHLPP在非小细胞肺癌中的表达及临床意义

Clinicopathological correlations of PHLPP expression in non-small cell lung cancer

目的探讨PHLPP在非小细胞肺癌(NSCLC)中的表达及临床意义。方法采用免疫组织化学染色的方法检测82例NSCLC组织中PHLPP蛋白的表达情况,并结合临床及病理因素进行相关性分析。结果 PHLPP主要在细胞膜上表达,在NSCLC中63%阴性表达、11%为+、10%为++、16%为+++,PHLPP的表达与NSCLC的分化程度存在显著相关性(P=0.024),与年龄、性别、吸烟状况、病理类型及分期没有显著相关性。结论 PHLPP蛋白在人NSCLC组织中表达率为37%,与NSCLC的分化程度有相关性。

Objective To investigate the expression of PHLPP in non-small cell lung cancer （NSCLC）and its correla-tions of clinicopathological characteristics. Methods All of 82 tissue specimens with NSCLC were examined with im-munohistochemical staining, and the results of IHC were analyzed with the clinicopathologic characteristics. Results PHLPP mainly expressed on the cell membrane. The rate of PHLPP expression was negative in 63%, poor in 11%, moderate in 10% and strong in 16%, respectively. The expression of PHLPP was significantly correlated with differen-tiation, but not with age, smoking states, pathological type and stage. Conclusion The positive expression rate of PHLPP is 37%in human NSCLC tissue specimens and was correlated with histological differentiation .