摘要
目的：通过老年抑郁症合并慢性心衰患者血清中N末端-前B型钠尿肽（NT-proBNP）和同型半胱氨酸（Hcy）的监测，观察其临床变化对老年抑郁症慢性心衰患者的诊断价值和近期疗效评估。方法选择经临床确诊的老年抑郁症慢性心衰患者（NYHAⅠ-郁级）80例（A组）及体检健康者50例（B组），分别检测其NT-proBNP和Hcy水平。并检测A组经正规治疗后NT-proBNP和Hcy水平变化，对检测结果对比分析。结果A组患者NT-proBNP（u=9.55）和Hcy（u=9.24）水平明显高于B组，差异有显著统计学意义（P〈0.01）。 A组患者治疗后NT-proBNP（u=4.83）和Hcy（u=7.65）的水平显著低于治疗前，差异有显著统计学意义（P〈0.01）。结论将NT-proBNP和Hcy联合检测有助于老年抑郁症合并慢性心衰的诊断，并可作为近期疗效评价指标。
Objective To evaluate the efficacy and diagnostic value of NT-proBNP and homocysteine （Hcy） levels in the serum of elderly depression with chronic heart failure. Methods The clinical diagnosis of depression in the elderly patients with chronic heart failure （NYHAⅠ-Ⅳ grade）80 cases （group A）and 50 cases of healthy subjects（group B）, NT-proBNP and Hcy levels were detected. Well which were detected in group A,comparative analysis of results before and after conventional therapy. Results The levels of NT-proBNP（u=9.55） and Hcy （u=9.24） was significantly higher in group A than those in group B, the difference was statistically significant （P〈0.01）. And the levels of NT-proBNP （u=4.83）and Hcy （u=7.65）were significantly lower in group A after treatment than those of before treatment,the difference was statistically significant（P〈0.01）. Conclusion NT-proBNP and Hcy joint detection can help diagnose depression in the elderly patients with chronic heart failure,and as a short-term effect evaluation.
出处
《中国现代医生》
2014年第27期54-56,共3页
China Modern Doctor
基金
浙江省科技厅项目(2012C23071)
关键词
抑郁症
慢性心衰
N末端-前B型钠尿肽
同型半胱氨酸
Depression
Chronic heart failure
N-terminal-pro-B-type natriuretic peptide
Homocysteine
