结核性胸腔积液实验室检测方法的研究进展

Advanced laboratory testings for tuberculous pleural effusions

结核性胸膜炎(TP)是引起渗出性胸腔积液最常见的病因。胸液微生物检查常常阴性。胸膜活检和胸腔镜检查的临床应用因其侵入性而受到限制。通过不懈努力已经推出了一系列无需侵入性操作就可有助诊断的胸腔积液实验室检查。本文就结核性胸膜积液(TPE)的特征进行讨论,以助诊断,重点介绍特异性生物标记试验,包括ADA、干扰素及其他新的检验方法的临床应用研究进展。

Tuberculous pleurity（TP）is the most important cause for exudative pleural effusions. Microbiological anal-yses of pleural fluid maybe negative in the most setting. Techniques, such as pleural biopsy or thoracoscopy are clini-cally limited by its invasion. Ongoing research has led to implementing a number of additional fluid analyses that may lead to a diagnosis without a need for further invasive procedures. In this review, we discuss the characteristics of TPE that may assist in this important diagnosis, and we highlight the benefits of specific biomarker analyses including adenosine deaminase, interferon and some novel tests.