自动温度仪法测定晶核诱导下L-阿拉伯糖介稳区的研究(英文)

Determination of Seeded Metastable Zone Width of L-Arabinose by an Automated Temperature Logging Device

介稳区测定对L-阿拉伯糖的工业化生产有很强的指导作用,但还没有文献报道过L-阿拉伯糖介稳区。本文采用自动温度记录仪法测定了L-阿拉伯糖的介稳区宽度。通过对比聚焦光束反射仪法数据,发现自动温度记录仪法所得到的数据真实可靠。对L-阿拉伯糖成核温度及其影响因素进行多重线性回归分析,发现成核温度与溶液浓度和搅拌速度呈正相关,浓度越高成核温度越高,成核温度也随着搅拌速度的增大而增高,冷却速度对成核温度没有显著性影响。研究发现在水溶液中L-阿拉伯糖的介稳区并非一个常数而是一个介于27.36到31.55℃的区间。相比于纯水系统,添加2%和4%的杂质(氯化钠、半乳糖、葡萄糖和木糖)均能降低L-阿拉伯糖的介稳区宽度。通过研究发现自动温度记录仪法是一种结构简单、价格低廉、检测结果可靠的实用方法,它可替代其它昂贵的结晶检测仪器应用于生产实践过程中。

Determination of the metastable zone width （MSZW） is of great importance in L-arabinose crystallization, yet it has not been reported before. In this study, the use of an automated temperature logging device （ATLD） to monitor the nucleation temperature （Tin） of L-arabinose in an aqueous solution was demonstrated. Direct comparison with focused beam reflectance measurements （FBRM） confirmed that the Tm determined by the ATLD was reliable. A multiple linear regression model of the Tm and a set of exploratory factors indicated that the Tm was affected by the solution concentration and stirring rate but not the cooling rate. The MSZW of L-arabinose in an aqueous solution was not constant, but ranged from 27.36 to 31.55 ℃.The addition of 2% and 4% impurities （sodium chloride, galactose, glucose, and xylose） decreased the MSZW of L-arabinose. This study offers new opportunity for the use of ATLD as simple, inexpensive, and convenient alternative tool in crystallization monitoring.