γδT细胞对组织相容性复合体Ⅰ类分子配体识别研究的进展

γδT cell receptor ligands and modes of major histocompatibility complex Ⅰ recognization

背景 γδT细胞是T细胞的一个亚群,其抗原受体在包括抗病原体、抗肿瘤、过敏反应、自身免疫疾病等免疫应答中都有一定的作用,而主要组织相容性复合体（major histocompatibility complex,MHC）Ⅰ类分子是其受体的主要配体之一。目的 通过在体研究已经发现γδT细胞识别抗原的模式具有多态性。对其中的MHC Ⅰ类分子的研究回顾,是了解γδT细胞受体和抗原识别模式部分特征的途径之一。内容 介绍γδT细胞受体免疫学特点,总结可作为配体被其受体识别的MHC Ⅰ类分子。趋向 MHC Ⅰ类分子作为γδT细胞受体配体的一种类型,其对γδT细胞受体识别模式研究的不断进展具有重要意义。

Backgroud T lymphocytes expressing the γδ-type of T cell receptors （TCR） for antigens contribute to all aspects of immune responses,including defenses against pathogene,tumors,allergy and autoimmunity,and major histocompatibility complex （MHC） Ⅰ molecules is one of major γδTCR ligands.Objective Multiple subsets have been individualized in humans as well as in mice and they appear to recognize in a TCR-dependent manner antigens implying diverse modes of antigen recognition.Reviewing the MHC Ⅰ molecules as one of major γδTCR ligands which is one way of discussing the possible character of γδTCR and γδT cells antigen recognition modes.Content The review introduces the character of γδT cells,then describes MHC Ⅰ molecules that can be recognized as ligands of γδTCR.Trend It is important that confirming the modes of γδT cells antigen recognition further more by the study of MHC Ⅰ molecules as specific ligands of γδ TCR.