期刊文献+

结缔组织生长因子在椎间盘退行性病变过程中的机制研究

下载PDF
导出
摘要 1结缔组织生长因子(CTGF)的结构域和功能:CCN 家族由6名成员组成,每个家族成员都包含4个保守的功能域。每个功能域能够独立性和合作性的发挥CCN 家族成员的整体功能。胰岛素样生长因子结合蛋白功能域和von Wille-brand 因子C(von Wille-brand factor C VWC)同时被绑定到聚集蛋白聚糖。VWC 域还结合骨形态发生蛋白和转化生长因子β,整合素和基质金属蛋白酶。
作者 袭开春
出处 《中国伤残医学》 2014年第19期202-203,共2页 Chinese Journal of Trauma and Disability Medicine
  • 相关文献

参考文献6

二级参考文献23

  • 1[2]Antoniou J, Steffen T, Nelson F, et al. The human lumbar intervertebral disc evidence for changes in the biosythesis and degeneration of the extracellular matrix with growth, maturation, ageing, and degeneration[ J] . J Clin Invest, 1996,98:996 - 1003
  • 2[5]Moses HL, Serra R. Regulationg of differentiation by TGF - beta[J]. Curr Opin Genet Deve, 1996,6:581 -586
  • 3[6]Grotendorst GR. Connective tissue growth factors: mediator of TGF -beta action on fibroblasts [ J ]. Cytokine Growth Factor Rev,1997,8:171 - 179
  • 4龙厚清,胡有谷,李佛保.腰椎间盘中碱性成纤维细胞生长因子的表达[J].中华实验外科杂志,2001,18(增刊):55-56.
  • 5Border WA, Noble NA. Transforming growth factor β in tissue fibroses. N Engl J Med, 1994,331: 1286-1292.
  • 6Brigstoce DR. The connective tissue growth factor/cysteinerich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev, 1999, 20: 189-206.
  • 7Grotendorst GR. Connective tissue growth factor: a mediator of TGF-β action on fibroblasts. Cytokine Growth Factor Rev,1997, 8: 171-179.
  • 8Chen MM, Lain A, Abraham JA, et al. CTGF expression is induced by TGF-I3 in cardiac flbroblasts and cardiac myocytes:a potential role in heart fibrosis. J Mol Cell Cardiol, 2000,32: 1805-1819.
  • 9Gupta S, Clarkson MR, Duggan J,et al. Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int, 2000, 58: 1389-1399.
  • 10Ito Y, Aten J, Bende RJ, et al. Expression of connective tissue growth facet in human renal ilbrosis. Kidney Int,1998, 53: 853-861.

共引文献42

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部