脑卒中患者颈动脉粥样斑块发生与Hcy水平的相关性

Research on the relationship between carotid atherosclerosis and concentration of homocysteine in ischemic stroke patients

目的探讨缺血性脑卒中患者颈动脉粥样斑块发生情况与血清同型半胱氨酸水平的相关性。方法对缺血性脑卒中住院患者,应用彩色多普勒超声检测颈部血管内中膜厚度及斑块形成情况,并同期检测患者血清同型半胱氨酸浓度。结果 236例病例组患者中,183例检出颈动脉粥样硬化斑块,发生率为77.54%;260例对照组检出颈动脉粥样硬化斑块60例,发生率为23.07%,缺血性脑卒中组粥样硬化斑块发生率明显高于对照组(P<0.01)。缺血性脑卒中患者平均血清同型半胱氨酸水平显著高于对照组(P<0.05),且同型半胱氨酸水平与颈动脉粥样硬化的程度及硬化斑块的性质相关(P<0.05)。结论缺血性脑卒中患者颈动脉粥样硬化斑块发生与血清同型半胱氨酸水平之间有密切的相关性。

Objective To evaluate the relationship between carotid atherosclerosis and concentration of homocysteine in ischemic stroke patients. Methods Colour ultrasonic Doppler examination was used for examination of neck vascular intima-media thickness and plaque formation of carotid artery atherosclerosis and concentration of homocysteine in ischemic stroke patients and controls. The relationship between conditions of carotid artery atherosclerosis and the concentration of homocysteine was analyzed. Results Among 236 patients with the ischemic stroke, arteriosclerosis spots at the segment outside skull of carotid was observed in 183 cases （77.54%） , while abnormality arteriosclerosis spots was noticed in 60 cases in the control group （23.07%）,showing significant difference between the two groups（P 〈0.01）. The average concentrations of homocysteine were significantly higher in ischemic stroke patients than that of the controls, and the levels of homocysteine was correlated with the degree and the stability of carotid artery atherosclerosis. Conclusion The high plasma level of homocysteine is strongly associated with carotid atherosclerosis in ischemic stroke patients.