少突胶质细胞瘤1p/19q检测临床意义研究

Clinical significance of 1p/19q detection in oligodendroglioma

目的研究少突胶质细胞瘤样本1p/19q染色体缺失与患者预后的关系。方法用荧光原位杂交方法检测37例少突胶质细胞瘤样本,分析样本中1p/19q缺失情况。结果在对37例样本的检测中,1p缺失25例(67.5%)、19q缺失23例(62.2%)、1p/19q共缺失20例(54.1%)。其中少突胶质细胞瘤正常组、1p/19q共缺失、仅1p缺失和仅19q缺失平均生存时间分别为41、85、67和45个月,中位生存时间分别为41、85、78和64个月。1p/19q共缺失和1p缺失患者的预后较正常组和19q缺失组更好。结论 1p/19q染色体缺失是少突胶质细胞瘤的重要分子生物学标志物,在预后判断,肿瘤分层上有重要意义。

Objective To detect the incidence of 1p/19 q loss of heterozygosity in oligodendroglioma,and to explore the relationship between them and prognosis of patients.Methods 1p/19 q deletion was analyzed by fluorescence in situ hybridization in thirty-seven oligodendroglioma specimens.Results Of the 37 cases,there are 25 cases（67.5%） with 1p deletion,23 cases（62.2%） with 19 q deletion,and 20 cases（54.1%） with 1p/19 q co-deletion.The average survival time in normal group,1p/19 q co-deletion group,lp deletion group and 19 q deletion group was 45、41 、85 and 67,respectively.And the median survival time was40.67,85.08,78.33 and 40.67,respectively.The prognosis of patients with 1pA9 q co-deletion and 1p deletion were better than normal group and 19 q deletion.Conclusion 1p/19 q deletion,as an important molecular marker,plays critical roles in prognosis and stratification of oligodendrogliomas.