基于熵聚类与apriori算法的脾虚型泄泻用药规律研究

Composition Principles of Prescriptions for Diarrhoea Caused by Spleen Deficiency Based on Entropy Clustering and Apriori Method

目的探讨治疗脾虚型泄泻方剂的组方用药规律。方法应用中医传承辅助系统(V1.3),收集、整理《中医方剂大辞典》中治疗脾虚型泄泻的方剂,构建数据库,利用熵聚类与apriori算法进行组方规律分析。结果对所筛选出的1185首方剂、815味中药进行分析,使用频次≥50次的药物有33味、常用药对50个,使用频次≥40次的药物组合29个,对支持度≥20%、置信度≥0.9的方剂进行关联规则分析,得到用于新方聚类的核心药物组合19对及19个候选新处方;以四君子汤的药物组成进行方剂匹配,相似度阈值为0.5,得出17首匹配处方。结论治疗脾虚型泄泻组方多以健脾益气为主,温阳渗湿止泻为辅。

Objective To analyze composition principles of prescriptions for the treatment of diarrhoea caused by deficiency of spleen. Methods The prescriptions for diarrhoea caused by deficiency of spleen in the Prescriptions of Traditional Chinese Medicine Dictionary were collected, sorted and entered into the TCM Inheritance Support System （V1.3） to analyze the composition principles through the methods of entropy clustering and apriori. Results Based on the analysis of 1185 prescriptions and 815 medications, there were 33 medications with more than 50 frequencies. Composition principles were obtained through apriori method：50 herbal pairs were used with more than 50 frequencies, and 29 core combinations with more than 40 frequencies. Association principle rule were used for the analysis of those medications in the prescriptions （support≥20%, confidence≥0.9）. Principles were obtained through entropy clustering：there were 19 core combinations which composed the new prescriptions, and 19 new prescriptions were found through hierarchical clustering method. There were 17 prescriptions matching with Sijunzi decoction （semblance=0.5）. Conclusion Diarrhoea caused by deficiency of spleen should be treated with strengthening spleen and benefiting qi primarily, assisting with warming yang, excreting dampness and checking diarrhoea.