胃癌周围淋巴结转移相关因素的分析

Analysis of risk factors for lymph node metastasis in gastric carcinoma

目的探讨影响胃癌淋巴结转移的相关因素,为选择合适的治疗方案提供参考依据。方法回顾性分析190例胃癌患者临床病理资料与淋巴结转移的关系。结果肿瘤直径≥5 cm和肿瘤直径3-5 cm的淋巴结转移率(80.65%和71.15%)明显高于肿瘤直径≤3 cm的淋巴结转移率(35.56%)(P<0.05)。侵及浆膜下层及其以外的淋巴结转移率(76.71%)明显高于仅侵及黏膜或黏膜下层和侵及肌层的淋巴结转移率(33.33%和38.46%)(P<0.05)。不同性别、年龄、肿瘤原发部位以及不同细胞类型的淋巴结转移率差异没有统计学意义(P>0.05)。结论肿瘤大小、浸润深度是影响胃癌周围淋巴结转移的独立危险因素,应根据肿瘤大小和浸润深度选择合适的治疗方案。

Objective To explore the risk factors for lymph node metastasis in gastric carcinoma for putting forward a suitable therapy for gastric carcinoma.Methods The data of 190 patients with gastric carcinoma were retrospectively reviewed,and the relationship between clinicopathological characteristics and lymph node metastasis was analyzed.Results The lymph node metastasis rate of tumor diameter ≥5 cm（80.65％）and 3-5 cm（71.15％）were significantly higher than that of tumor diameter≤3 cm（35.56％） （P ＜ 0.05）.The lymph node metastasis rate of serosa invasion or penetrate serosa invasion（76.71％）was significantly higher than that of mucosal and submucosal tumors invasion （33.33％）or lamina muscularis invasion （38.46％） （P ＜ 0.05）.There was no relations between gender,age,tumor site,histological type and lymph node metastasis （P ＞ 0.05）.Conclusion The tumor size and depth of invasion are the dangerous risk factors of the lymph node metastasis in gastric carcinoma.The tumor size and the depth of invasion should be considered in the lymph node dissection of gastric carcinoma.