精神分裂症血糖、血脂及QTc间期的性别差异

Gender difference of blood sugar,lipids and QTc interval in patients with schizophrenia

目的调查精神分裂症患者血糖、血脂及QTc间期的性别差异。方法对稳定剂量抗精神病药治疗的522例住院精神分裂症患者进行横断面调查,收集人口学资料、临床特征、空腹血糖和血脂等生化指标、心电图资料,分析性别差异。结果男性PANSS阴性分高于女性(21±7 vs 20±9,P<0.05),一般症状分低于女性(26±5 vs 28±6,P<0.05),女性空腹血糖、总胆固醇等高于男性[空腹血糖(5.70±1.51)mmol/L vs(5.32±0.95)mmol/L,总胆固醇:(4.95±1.05)mmol/L vs(4.48±0.93)mmol/L](P<0.01),女性QTc间期延长发生率高于男性(22.7%vs 7.8%,P<0.001)。结论精神分裂症存在临床特征、生化指标、QTc间期等性别差异。

Objective To investigate the gender difference of blood sugar,lipids and QTc interval in schizophrenia inpatients.Methods In this cross-sectional study,a total of 522 inpatients treated with stable dosages of antipsychotics were investigated.The demographic and clinical data,the biochemical indices such as fasting blood sugar and lipids,the electrocardiograms （ECG） data were collected to analyze the gender difference.Results The PANSS negative score of male was higher than that of female （21 ± 7 vs 20 ± 9,P ＜ 0.05）,while the PANSS common symptom score was lower （26 ± 5 vs 28 ± 6,P ＜ 0.05）.The levels of fasting blood sugar [（5.70 ± 1.51） mmol/L vs （5.32 ± 0.950） mmol/L,total cholesterol in female were higher than those in male [（4.95 ± 1.05） mmol/L vs （4.48 ± 0.93）mmol/L] （P ＜ 0.01）,while the QTc prolongation prevalence was higher in female than that in male （22.7％ vs 7.8％,P ＜0.001）.Conclusion The results suggest that there is gender difference in clinical characteristics,biochemical indices and QTc interval in schizophrenia patients.