精子抗原表位的研究进展

Progress in research of sperm antigenic epitopes

精子是一种隐蔽抗原,可引起机体产生抗精子抗体。抗精子抗体能够影响生殖细胞的结合、胚胎着床等过程,进而导致免疫性不孕不育。近年来,与免疫性不孕不育密切相关的抗精子抗体所结合的精子表面抗原及其抗原表位已成为抗精子抗体检测及避孕疫苗的主要研究对象之一。该文对与免疫性不孕不育相关的精子表面抗原及其抗原表位的筛选和鉴定,以及当前精子抗原表位研究所面临的难点作一简要的综述。

Sperm is a kind of inaccessible antigens that can lead to synthesize anti-sperm antibody potential-ly.The binding of anti-sperm antibody to sperm surface antigen may affect some biological processes , such as the for-mation of fertilized egg and embryo implantation , and thus result in immunological infertility .In recent years , sperm surface antigen and its epitopes combining with anti-sperm antibody related to immunoinfertility have become one of the major research objects in the research of anti-sperm antibody detection and contraceptive vaccines preparation .In this paper , we review briefly the screening and identification of sperm surface antigen as well as its epitopes related to immunoinfertility and the challenges that the research faces .