降脂消斑片对动脉粥样硬化兔VEGF与主动脉病理变化的影响

Effects of Jiangzhi Xiaoban Pills on VEGF and the Aorta of Pathological Changes in Atherosclerotic Rabbits

目的:观察降脂消斑片对动脉粥样硬化兔VEGF与主动脉病理变化的影响。方法:运用高脂高胆固醇饲料喂养12周以造成日本大耳白兔动脉粥样硬化模型,用降脂消斑片灌胃给药治疗4周,采用双抗体夹心酶联免疫吸附法检测血清中VEGF的含量,同时观察主动脉及粥样硬化斑块病理学改变。结果:与模型组比较,降脂消斑片能明显降低血清中VEGF的含量,差异有统计学意义(P<0.01);病理学结果显示,降脂消斑片干预后,主动脉粥样斑块面积减少、斑块厚度变薄,斑块较非干预组稳定。结论:降脂消斑片可以降低兔AS模型血清中VEGF的含量,减轻主动脉粥样硬化斑块及血管内膜的脂质浸润程度,稳定动脉粥样硬化斑块。

Objective： To observe the effects of Jiangzhi Xiaoban pills on VEGF and the aorta of pathological changes in atherosclerotic rabbits. Methods： High cholesterol diet was applied to induce the rabbit models for 12 weeks, with intragastric administration with Jiangzhi Xiaoban pills for 4 weeks;the serum levels of VEGF in the rabbits was detected by double antibody sandwich enzyme-linked immunosorbent method, and the aorta of pathological changes were observed in atherosclerotic rabbits. Results： Comparing with the model group, the Jiangzhi Xiaoban pills could decrease significantly the serum levels of VEGF, and the difference was statistically significant（P〈0.01）;Pathology showed that the intervention of Jiangzhi Xiaoban pills decreased the area of atherosclerotic plaque and caused the plaque to thinner and stable. Conclusion： The Jiangzhi Xiaoban pills can inhibit the serum levels of VEGF, lessen the aorta of atherosclerotic plaque and the intimal of lipid infiltration, and stabilize the atherosclerotic plaques.