贵阳市部分成人代谢综合征对骨密度的影响

Association between metabolic syndrome and bone mineral density

目的：了解代谢综合征及其组分对骨密度的影响。方法2009年11月至2010年2月贵阳市居民健康横断面调查的1512名20～79岁调查对象（男性636名，女性876名）纳入本研究，受试者平均年龄（45.3±14.4）岁。对所有受试者进行问卷调查及体格检查，用OLYMPUSAU5400全自动生化分析仪检测空腹静脉血糖及餐后2h血糖、三酰甘油、高密度脂蛋白胆固醇、血钙、血磷、血肌酐及血尿酸，用ROCHE化学发光法测定血清胰岛素；用双能X线检测股骨颈、全髋、Wards三角、粗隆及腰椎正位（L1-4）骨密度。结果完成血脂、尿酸、血糖、血钙、血磷、血肌酐、血胰岛素及骨密度检测者1216名，发现代谢综合征患者356例，患病率为29.3％，其中男性125例（35.1％），女性231例（64.9％）；代谢综合征组骨折患病率为5.1％，非代谢综合征组为3.3％；代谢综合征患者全髋及粗隆骨密度较非代谢综合征者高[（0.95±0.15）g/cm2比（0.93±0.14）g/cm2；（0.76±0.13）g/cm2比（0.73±0.12）g/cm2；均P＜0.01]；校正性别及年龄后，股骨颈、全髋、Wards三角、粗隆及L1-4骨密度值均随代谢综合征患者组份增加而增高（均P＜0.01）。结论代谢综合征患者有较高的全髋及粗隆骨密度，但其骨折率亦较高。

Objective The aim of the study is to assess the impact of metabolic syndrome （ MS） and its multi-component on bone mineral density （BMD）.Methods We conducted a cross-sectional evaluation of 1512 participants in the general community from November 2009 to February 2010 Guiyang Health Measures Survey .The mean age was 45.3 ± 14.4years.All the subjects underwent questionnaire , anthropometric measurements , blood biochemical analyses .Fasting plasma glucose, 2-hour plasma glucose, serum triglycerides, high density lipoprotein cholesterol, insulin, calcium, phos-phorus , creatinine and uric acid were measured by automatic biochemical analyzer （ OLYMPUS AU5400 ） .Plasma insulin were measured by Chemiluminescence method （ROCHE）.The BMD （g/cm2） of the femoral neck, Wards, trochanter, total hip and lumbar spine （ L1-4 ） were measured using a lunar prodigy scanner [ GE Medicail System （ China ） Co. Ltd].Results The prevalence of MS was 29.3% （356 person） of the complete data objectives （1 216 person）, within 125 male （35.1%） and 231 female （64.9%）, respectively.The prevalence of fracture in MS was higher than Non-MS slightly （5.1%in comparison with 3.3%）. In comparison with Non-MS, all BMD values were higher in the MS groups , although only significantly different for total hip and femoral trochanter （ P〈0.01 ） , After age and gender ad-justed, a gradual increase of mean levels BMD of all sits was seen when the components of MS was from one up to five （ P〈0.01 ） .Conclusion Our study suggests that the MS group represented a higher BMD of total hip and femoral tro -chanter, while also indicated a higher fracture rate than Non-MS group.