血小板抗体筛选及血小板交叉配型对血小板输注效果的影响

Effect of Platelet Crossmatch and Platelet Antibody Screening for Platelet Transfusion

目的:探讨血小板抗体筛选及血小板交叉配型在临床的应用及其对血小板输注效果的影响,为临床合理用血提供参考。方法:选择384例临床输注血小板患者,随机分为对照组及研究组,对照组给予常规方法输注血小板,研究组患者输注前检测血小板抗体,抗体阴性患者给予常规输注血小板,血小板抗体阳性患者给予血小板交叉配型后输注血小板,比较两组患者血小板输注临床效果。结果:对照组患者输注有效率为91.4%,研究组输注有效率为95.5%,两组患者输注有效率比较差异无统计学意义(P>0.05),研究组输注后1 h及24 h CCI为9.6±1.8和7.2±1.6,对照组输注后1 h及24 h CCI为8.9±1.9和6.1±1.4,研究组输注后1 h及24 h CCI高于对照组(P<0.05)。结论:血小板输注前常规进行血小板抗体筛选,血小板抗体阳性患者进行交叉配型能够改善血小板输注效果。

Objective：To investigate the application and effect of platelet crossmatch and platelet antibody screening for platelet transfusion,and provide reference for reasonable use of blood in clinic.Method：384 cases of patients who transfuse platelet were selected and randomly divided into research group and control group,platelet in the control group were transfused with common ways,and platelet antibody was detecting before platelet transfusion in research group,and platelet were transfused with common ways in patients with negative antibody,and platelet were transfused after crossmatch in patients with positive antibody,and transfuse effect were contrasted between research group and control group.Result：Effective rate of platelet transfusion was 91.4% in control group and was 95.5% in research group,effect rate in two groups had no significant difference（P〉0.05）,and CCI at 1 hour and 24 hours after transfusion was 9.6±1.8 and 7.2±1.6 in research group,CCI at 1 hour and 24 hours after transfusion was 8.9±1.9 and 6.1±1.4 in control group,CCI at 1 hour and 24 hours after transfusion was higher in research groups than those in control group（P0.05）.Conclusion：Platelet antibody screening should be taken before platelet transfusion and platelet crossmatch in patients with positive antibody,it can improve effect of platelet transfusion.