芪药消渴胶囊逆转2型糖尿病慢性肾脏疾病白蛋白尿的临床观察

Study on QiyaoXiaoke capsule reversing microalbminurina in chronic kidney disease of type 2 diabetes mellitus

目的 观察芪药消渴胶囊对糖尿病慢性肾脏疾病（CKD）白蛋白尿的影响. 方法 采用多中心、随机、双盲、安慰剂对照试验,共224例UAlb/Cr 30～299 mg/24 h患者纳入研究,其中试验（Tre）组116例,对照（PC）组108例,两组在接受常规治疗的基础上,Tre组加用芪药消渴胶囊,PC组加用安慰剂,治疗16周.比较两组治疗前后UAlb/Cr、肾功能、血糖、血脂等指标的变化. 结果 与治疗前相比,治疗后两组UAlb/Cr、肾功能、血糖、血脂等指标均有所改善（P＜0.05）,Tre组与PC组相比差异有统计学意义（P＜0.05）. 结论 芪药消渴胶囊能够逆转患者UAlb/Cr 30～299 mg/24 h水平,保护肾功能,延缓CKD的进展.

Objective To observe the influence of QiyaoXiaoke capsule on rnicroalbminurina in T2DM with chronic kidney disease （CKD）. Methods The multicenter, randomized, double-blind and placebo control experiments were performed in this study. 224 eases of patients with CKD were observed, which was divided into trial （Tre） group with 116 patients and placebo control （PC） group with 108 patients. Two groups were treated with routine treatment for 16 weeks, Tre group was given QiyaoXiaoke capsule as add-on therapy to the routine treatment, PC group was given placebo capsule. The aim was to compare blood glucose, blood lipid, renal function, UAlb/Cr. Results After treatment, UAlb/Cr, renal function, blood glucose and blood lipid are improved （P〈0.05）. In addition, the improvement in Tre group was superior to that in PC group （P〈0.05）. Conclusion QiyaoXiaoke capsule can reverse microalbuminuria in CKD, protect renal function, and delay the progression of CKD.