银杏叶片和银杏酮酯片的质量比较和用药成本分析

Comparative Research of Quality and Analysis of Pharmacoeconomics in Two Kinds of Ginkgo Biloba Leaves Preparations

目的比较市售3个厂家银杏叶片和银杏酮酯片、2个厂家银杏叶提取物和银杏酮酯中总黄酮、总黄酮醇苷和萜类内酯的含量,为评价2种制剂的质量提供依据;并分析2种银杏叶制剂的药物经济学。方法通过交叉试验,采用UV检测2种制剂和原料药中总黄酮的含量,采用HPLC检测2种制剂和原料药中总黄酮醇苷和萜类内酯的含量。结果 2种制剂和原料药分别在总黄酮、总黄酮醇苷和萜类内酯的含量上均不存在显著性差异,但就患者日用金额考虑,银杏叶片更适合患者使用。结论银杏叶片较银杏酮酯片更适合用于临床上慢性疾病的治疗。

OBJECTIVE To compare the content of the total flavonoids, favonoid aglycones and terpene lactones in six companies＇ Ginkgo tablet and Ginkgo biloba L. tablet and two companies＇ Ginkgo biloba extract and Ginkgo biloba L. for evaluation the quality of two preparations; and then analyze the pharmaceutical economics of two preparations. METHODS According to the crossover trial, the total flavonoids of two preparations and raw materials were detected by UV, and the favonoid aglycones and terpene lactones were detected by HPLC. RESULTS All the content of the total flavonoids, favonoid aglycones and terpene lactones in two preparations and raw materials had no signifcant differences, but from the payment for single day, Ginkgo tablet was more suitable for patients. CONCLUSION Ginkgo tablet is better than Ginkgo biloba L. tablet in the treatment of chronic diseases.