重症病房金黄色葡萄球菌分布与耐药性分析

Distribution and Drug Resistance of Staphylococcus Aureus in ICU

目的了解临床感染金黄色葡萄球菌(SAU)的病原菌分布及其耐药性,为重症患者合理选用抗菌药物提供依据。方法收集济宁市第一人民医院重症监护病房患者SAU标本,按照《全国临床检验操作规程》标准分离、培养、鉴定细菌并判别药敏结果,对病原菌的分布及耐药情况进行回顾性分析。结果 2010-2012年临床分离210株SAU,其中耐甲氧西林SAU(MRSA)为132株,甲氧西林敏感SAU(MSSA)为78株。MRSA的分离率较高且对常用抗菌药物多有较高的耐药率。MRSA耐药率高于MSSA差异有统计学意义(P<0.05)。结论临床感染金黄色葡萄球菌的耐药性日趋严重,应加强细菌学培养与药敏试验,合理选择临床用物,以延缓耐药菌株的产生。

Objective To study the clinical Staphylococcus aureus Infection （SAU） distribution of pathogens and antibiotic resistance, and thus to provide a basis for selecting proper antibiotics for severe patients. Methods SAU specimens were collected in patients in ICU and were isolated, cultured and identified, the bacteria drug susceptibility results was also identified in accordance with the national standards of clinical laboratory practice. The distribution and drug resistance of pathogenic bacteria were analyzed retrospectively. Results During 2010 - 2012, 210 strains SAU were clinically isolated, including 132 Methicillin - resistant Staphylococcus aureus （MRSA） and 78 Methicillin- sensitive Staphylococcus aureus （MSSA）. Methicillin - resistant SAU （MRSA） exhibited relatively high separation rate and easy resistance to commonly antibiotics. MRSA showed higher drug resistance rate than MSSA （ P 〈 0. 05 ） Conclusion The drug resistance of SAU is growing more and more severe and thus culturing of bacteria, drug sensitive test and rational drug use should be strengthened to delay the generation of drug resistant strains.