乙肝肝衰竭患者临床输注新鲜冰冻血浆治疗效果分析

Efficacy of Clinical Infusion of Fresh Frozen Plasma in Patients With Hepatitis B Liver Failure

目的回顾性调查分析乙肝肝衰竭患者临床输注新鲜冰冻血浆(fresh frozen plasma,FFP)的资料,了解输注FFP对于改善预后的疗效。方法查阅2009-12/2013-07在四川省人民医院住院的88例乙肝肝衰竭患者,观察时间为4周,根据观察期间是否输注FFP分为2组,对照组31例未输注FFP,治疗组57例输注FFP,比较2组患者住院4周后和入院时的终末期肝病模型(Model for end-stage liver disease,MELD)评分,分析是否输注FFP和血浆用量对预后的影响,综合评估患者临床转归。结果对照组MELD评分差值1.74±12.12,治疗组MELD评分差值-0.46±8.03,2组比较差异无统计学意义(t'=-0.91,P>0.05)。治疗组的血浆用量和MELD评分差值使用直线相关分析,直线相关系数r=0.11 P>0.05,无直线相关关系。结论输注FFP不能改善乙肝肝衰竭患者的预后,不推荐预防性应用。

Objective To retrospective investigate and analyze patients with hepatitis B liver failure and treated with clinical infusion of fresh frozen plasma （FFP）, and to understand the curative effect of infusion FFP to improve prognosis. Methods During Dec. 2009 to July 2009 in Sichuan Provincial People＇s Hospital, data of 88 patients with hepatitis B liver failure were referred, with observation time period of 4 weeks. The patients were divided into patients with FFP treatment （57 cases） and patients without FFP treatment （31 cases）. The MELD score of the patients on admission to hospital and after 4 weeks were compared. The influence of infusion FFP and plasma dosage on prognosis were analyzed. Clinical outcomes were comprehensive evaluated. Results The score difference in non - FFP group was 1.74 ±12. 12 and - 0. 46 ± 8.03 in FFP group, no statistical difference was found between the two groups （t＇ = -0. 91, P 〉 0.05 ）. There was no linear relationship between usage of FFP and score difference. （ r = 0. 11, P 〉 0. 05 ） Conclusion Infusion FFP does not improve the prognosis of patients with hepatitis B liver failure and thus is not＇ recommended for preventive application.