白花蛇舌草的化学成分及药理作用研究进展

Advance on the Chemical and Pharmacological Effects Studies of Hedyotis diffusa

全面总结近几十年白花蛇舌草的化学成分、药理作用的研究进展,为白花蛇舌草临床应用及合理开发提供比较全面的参考依据。系统查阅中国知网、万方、PubMed、SpringerLink等国内外多个数据库,收集白花蛇舌草在化学成分、药理作用方面的文献,获取第一手资料,对其进行分析和归纳整理,形成综述。目前为止,该植物中已经发现的化学成分主要有萜类、黄酮类、蒽醌类、甾醇类等,其中萜类主要有三萜类和环烯醚萜类。药理研究结果显示白花蛇舌草最主要的活性是抗癌、抗氧化和抗炎等作用。白花蛇舌草在临床上常用于治疗多种癌症,尤其对食道癌,乳腺疾病作用明显,其主要活性部位为水提物和醇提物,主要有效成分为萜类等成分。本论文数据全面详实可靠,为进一步开展该植物的研究提供了文献资料。

To provide reference for the clinical application and rational development of Hedyotis diffusa, according to its recent development of research on the chemical constituents and pharmacological actions. Data of the chemical constituents and pharmacological actions of Hedyotis diffusa were collected, summarized and analyzed in domestic and foreign database such as CNKI, Wanfangdate, PubMed, SpringerLink, systematically. Terpenoids, flavonoids, anthraquinones, sterols, etc, were the main chemical composition in Hedyotis diffusa. Anticancer, antioxidant and anti-inflammatory effect were the main pharmacological effects of this drug. Treating a variety of cancers is the main clinic effect of this drug, especially the effect in the treating of esophageal cancer and breast disease. Water extract and alcohol extract were its main effective parts and terpenoids were its main effective components. The data mentioned above will provide reliable literature information for the further studies of this plant.