化学表观遗传修饰方法在真菌次级代谢产物研究中的应用

The application of chemical epigenetic modification method in the research of secondary metabolites from fungi

真菌产生的次级代谢产物是新药开发的重要资源,其生物合成过程受到众多因素的调控。化学表观遗传操作是利用小分子化学物质抑制真菌中影响表观遗传的酶类,激活沉默的生物合成基因,诱导真菌产生未知的次级代谢产物。化学表观遗传修饰已成为1种简单有效的发现结构新颖的活性次级代谢产物的新方法。本文综述了化学表观遗传修饰调控真菌次级代谢产物的研究进展,并对该方法用于海洋来源真菌次级代谢产物的研究进行了展望。

Fungi have proven to be the significant resources for development of new drugs.The biosynthesis of secondary metabolites in fungi is regulated by various factors.Chemical epigenetic manipulation is an approach that chemical small molecules are introduced to inhibit the fungal enzymes which influence the epigenetics.This method can activate the silence genes in fungi for the purpose of gaining access to hitherto unknown secondary metabolites.Therefore,chemical epigenetic modification has become a new method to obtain structurally novel and biologically active natural products simply and effectively.In this paper,the applications of chemical epigenetic modification method in the research of secondary metabolites from fungi were reviewed.And the perspective for the study on secondary metabolites from marine-derived fungi by this method was also prospected.