大肠癌合并糖尿病145例围术期治疗

Treatment for colorectal carcinoma in 145 paitients with diabetes mellitus during perioperative period

目的：探讨大肠癌合并糖尿病围术期的处理。方法回顾性分析1995年3月至2010年6月外科治疗的145例大肠癌合并糖尿病患者，其中常规组63例，围术期用短效正规胰岛素（ RI）；强化组82例，围术期用胰岛素强化治疗，比较两组术后并发症发生情况。结果145例患者均行择期手术，无手术死亡。术后并发症常规组明显多于强化组，差异有统计学意义（P﹤0.05）。结论大肠癌合并糖尿病围术期采用胰岛素强化治疗，能明显降低术后并发症，改善患者生活质量。

Objective To investigate the perioperative treatment of diabetic patients with colorectal carcinoma. Methods Form March 1995 to June 2010,145 patients with diabetes mellitus who underwent operations in our hospital were analyzed retrospectively,and conventional group had 63 examples, short-acting regular insulin was used in perioperative management;Intensive group had 82 examples,intensive insulin therapy was used in perioperative management. Postoperative complications were recorded. Results One hundred and forty-five cases all underwent elective operations,there was no operative death. The postoperative complications in intensive group was more than that in the conventional group, there was significant difference（ P﹤0. 05 ）. Conclusions It is very important to control blood glucose and urine glucose to normal level for elderly patients with colorectal and diabetes mellitus in perioperative period. Intensive insulin therapy used in mellitus perioperative management for cotorectal cancer with diabetes,can obviously reduce postoperative complications and improve the quality of life of the patients.