诱导性多能干细胞在儿童神经系统疾病中的应用

The progress of induced pluripotent stem cells in neural developmental diseases

诱导性多能干细胞（inducedpluripotentstemcell,iPS）是类似胚胎干细胞的一种细胞类型,可以通过对多种终末分化的体细胞外源性重编程诱导分化而成,其具有多能分化的潜能,进一步诱导生成神经细胞,为研究神经发育疾病、药物筛选及个体化治疗提供了种子细胞。该文对iPS细胞的研究进展及其在儿童神经系统疾病中的应用作一综述。

Induced pluripotent stem cell （ iPS cell ） , similar to embryonic stem cell, can be repro-grammed to the pluripotent state by ectopic expression of specific transcription factors. The iPS cells have pluri-potency and can be induced into neuron cells,which represent a promising cellular tool to study human neurode-velopmental disease,drug screening,diagnosis and personalized treatment. This article reviews the latest progress on iPS cell and its applications in neural developmental disease.