支气管肺发育不良的病因研究进展

Progress in the pathogenesis of bronchopulmonary dysplasia

支气管肺发育不良是早产儿致病和死亡的主要原因之一，因此支气管肺发育不良的病因及发病机制是目前新生儿医学研究热点之一。目前主要从先天因素包括遗传易患性和肺发育不成熟，后天因素包括氧中毒、气压伤和容量伤、感染或炎症反应。该文就近年来支气管肺发育不良新的病因及发病机制研究进展作一综述。

Bronchopulmonary dysplasia （ BPD） is a main cause of morbidity and mortality in preterm infant,so the etiology and pathogenesis of BPD is one of the hot issues in the neonatal medical research. Present studies,not only focus on the congenital factors,including genetic susceptibility and lung immaturity,but also the acquired factors,including oxygen toxicity,barotrauma and capacity of injury,infection or inflammation. This pa-per reviews recent research progress on the etiology and pathogenesis of new pulmonary hypoplasia.