慢性特发性血小板减少性紫癜发病机制研究进展

Advances in pathogenesis of chronic idiopathic thrombocytopenic purpura

特发性血小板减少性紫癜是一种异质性自身免疫性疾病，是儿童最常见的出血性疾病，尤其慢性患儿的健康相关生活质量受到严重影响，但其病因及发病机制目前仍不清楚。研究发现，遗传因素可能参与该病的发生及预后。该文从其危险因素、基因多态性和表达水平与其易患性及病情严重情况的关系、表观遗传的作用、慢性难治性特发性血小板减少性紫癜相关研究等方面作一综述。

Idiopathic thrombocytopenic purpura （ITP）,as a heterogeneous autoimmune disease,is the most common bleeding disorder,of which etiology and pathogenesis are still unclear. Health related quality of life are severely affected,especally in chronic patients . Studys on chronic idiopathic thrombocytopenic purpura pathogenesis ,both in China and abroad,have found that genetic factors may be involved in the occurrence and prognosis of the disease. The paper gives a review from the follow aspects,such as its risk factors,relationship between genetic polymorphisms or expression levels and chronic ITP susceptibility and seriousness,the role of epigenetic,researchs about chronic and refractory ITP,et al.