轻度胃肠炎伴婴幼儿良性惊厥248例临床及预后分析

Benign infantile convulsions with mild gastroenteritis：clinical and prognosis analysis of 248 cases

目的：探讨轻度胃肠炎伴婴幼儿良性惊厥的临床特点及预后。方法对248例符合轻度胃肠炎伴婴幼儿良性惊厥诊断的患儿进行临床分析,并随访12个月以上。结果发病年龄3月龄~3岁；1次病程中惊厥发作2次以上者124例,惊厥发作5min以上者64例；头颅CT/MRI检查、脑电图检查,均未见异常；血糖、血电解质均正常,脑脊液常规、生物化学检查正常,脑脊液细菌涂片和培养均为阴性；随访中有14例（5．6%）出现复发,12例（4．8%）出现热性惊厥,8例（3．2%）转化为癫疒间。结论轻度胃肠炎伴婴幼儿良性惊厥多数病例预后良好,少数病例有向热性惊厥及癫疒间转化的可能,在轻度胃肠炎伴婴幼儿良性惊厥后出现热性惊厥的患儿转化为癫疒间的可能性较大,且轻度胃肠炎伴婴幼儿良性惊厥在惊厥频繁发作时对中枢神经元会造成损伤,若再次有惊厥发作应及时就诊,以免延误诊治。

Objective To explore the clinical characteristics and the prognosis of benin convulsions as-sociated with mild gastroenteritis（ BICE） in children. Methods To study clinical features of 248 children with BCIE,they followed up for 12 months,and their prognosis were observe. Results Age between 3 months and 3 years,twice or more seizures were occurred on 124 patients. 64 patients suffered the seizures more than 30 mi-nutes. Cranial CT/MRI showed no abnormality. Laboratory examinations were normal, including plasma glu-cose,serum electrolytes and cerebrospinal fluid. Followed up for 12 months,14 patients （5. 6%） suffered from recurrence of BICE,12 patients （4. 8%） suffered from simple febrile seizures,and 8 patients （3. 2%） devel-oped epilepsy. Conclusion The prognosis is good in majority of cases,but some cases may transform febrile seizure or epilepsy. It is more likely to transform epilepsy,when the children suffer from febrile seizure.