超声药物电导入治疗颈部淋巴结结核

Ultrasound-mediated drug delivery treating cervical tuberculous lymphadenitis

目的 探讨超声药物电导入联合口服抗结核药物治疗颈部淋巴结结核的疗效.方法 选取2010年1月至2012年12月首都医科大学附属北京胸科医院初治的颈淋巴结结核患者168例,完全随机分为观察组和对照组,各84例.2组均采用规范四联抗结核药物口服治疗,即异炯肼0.3g,1次/d;利福平0.45 g,1次/d;乙胺丁醇0.75 g,1次/d;吡嗪酰胺0.5g,3次/d.观察组另加局部药物超声电导入治疗,即采用利福平溶液（含注射用利福平0.3g,5 ml）敷于体表结核部位,超声电导仪导入30 min.疗程均为2个月.结果 观察组治愈72例,显效6例,好转6例,治愈率为85.7％,总有效率为92.9％;对照组治愈19例,显效6例,好转10例,病变无明显变化40例,病情进展9例,治愈率为22.6％,总有效率为29.8％.观察组治愈率及总有效率均高于对照组,组间差异均有统计学意义（均P＜0.01）.结论 超声电导入联合规范抗结核药物治疗颈部淋巴结结核的效果优于单纯抗结核药物治疗.

Objective To investigate the efficacy of ultrasound-mediated drug delivery combined with oral anti-tuberculous （TB） drugs.Methods Totally 168 cases of initial tuberculosis treatment of cervical lymph nodes were randomly divided into observation group and control group.Both groups had standardized quadruple anti-TB drugs.The observation group also received ultrasound-mediated drug delivery including rifampicin solution for 2 months.Results The cure rate and total effective rate of the observation group was 85.7% （72/84） and 92.9% （78/84）.The cure rate and total effective rate of the control group was 22.6% （19/84） and 29.8% （25/84） ; there was a statistically significant difference between the cure rates and the total effective rates in the two groups.Conclusion The efficacy of ultrasound-mediated drug delivery combined with oral anti-TB drugs is superior to solo anti-TB medication treatment.